Deficiency of Dietary Fiber Modulates Gut Microbiota Composition, Neutrophil Recruitment and Worsens Experimental Colitis

• DOI: 10.3389/fimmu.2021.619366
• Publication Date: 2021-02-23T05:49:58Z
• Authors: Sj Shen; Kathryn Prame Kumar; Shu Wen Wen; Raymond Shim; Brooke J. Wanrooy; Dragana Stanley; Robert J. Moore; Thi Thu Hao Van; Remy Robert; Michael J. Hickey; Connie H. Y. Wong
• Keywords: Basal (medicine)

Ulcerative colitis is an inflammatory disease of the colon that associated with colonic neutrophil accumulation. Recent evidence indicates diet alters composition gut microbiota and influences host–pathogen interactions. Specifically, bacterial fermentation dietary fiber produces metabolites called short-chain fatty acids (SCFAs), which have been shown to protect against various diseases. However, effect deficiency on key initial steps inflammation, such as leukocyte–endothelial cell interactions, unknown. Moreover, impact recruitment under basal conditions during inflammation in vivo Herein, we hypothesized a fiber-deficient promotes state at baseline predisposes host more severe pathology. Mice fed no-fiber for 14 days showed significant changes exhibited increased neutrophil-endothelial interactions microvasculature. Although mice alone did not observable colitis-associated symptoms, these animals were highly susceptible low dose (0.5%) dextran sodium sulphate (DSS)-induced model colitis. Supplementation most abundant SCFA, acetate, prevented diet-mediated enrichment neutrophils Therefore, fiber, possibly through actions plays important role regulating protection damage experimental