IL-17+ Mast Cell/T Helper Cell Axis in the Early Stages of Acne

• DOI: 10.3389/fimmu.2021.740540
• Publication Date: 2021-09-28T09:48:31Z
• Authors: Yoan Eliasse; Edouard Leveque; Lucile Garidou; Louise Battut; Brienne McKenzie; Thérèse Nocera; Daniel Redoules; Eric Espinosa
• Keywords: Thymic stromal lymphopoietin; Interleukin 33

Acne is a multifactorial disease driven by physiological changes occurring during puberty in the pilosebaceous unit (PSU) that leads to sebum overproduction and dysbiosis involving notably Cutibacterium acnes . These PSU microenvironment lead shift from homeostatic an inflammatory state. Indeed, immunohistochemical analyses have revealed inflammation lymphocyte infiltration can be detected even infraclinical acneic stages, highlighting importance of early stages disease. In this study, we utilized robust multi-pronged approach included flow cytometry, confocal microscopy, bioinformatics comprehensively characterize evolution infiltrating resident immune cell populations lesions, beginning their development. Using discovery cohort 15 patients, demonstrated composition infiltrate highly dynamic nature, with relative abundance different types changing significantly as function clinical lesion stage. Within examined, identified large population CD69 + CD4 T cells, several activated antigen presenting mast cells producing IL-17. IL-17 were preferentially located rich areas showed license produce Our study reveals are main producers stage acne, underlying targeting cell/T helper axis therapeutic approaches.