Dietary β-Carotene on Postpartum Uterine Recovery in Mice: Crosstalk Between Gut Microbiota and Inflammation

• DOI: 10.3389/fimmu.2021.744425
• Publication Date: 2021-11-30T22:23:15Z
• Authors: Xizi Yang; Ziyu He; Ruizhi Hu; Jiahao Yan; Qianjin Zhang; Baizhen Li; Xupeng Yuan; Hongfu Zhang; Jianhua He; Shusong Wu
• Keywords: Akkermansia; Litter; Carotene

As the precursor of vitamin A, β-carotene has a positive effect on reproductive performance. Our previous study shown that can increase antioxidant enzyme activity potentially through regulating gut microbiota in pregnant sows. This aimed to clarify performance and postpartum uterine recovery from aspect inflammation by using mouse model. Twenty-seven 6 weeks old female Kunming mice were randomly assigned into 3 groups (n=9), fed with diet containing 0, 30 or 90 mg/kg β-carotene, respectively. The results showed dietary supplementation reduced hyperemia mass index ( P <0.05), improved intestinal villus height crypt depth ratio, decreased serum TNF-α IL-4 concentration while no differences observed litter size weight among three treatments. Characterization revealed up-regulated relative abundance genera Akkermansia , Candidatus Stoquefichus Faecalibaculum but down-regulated Alloprevotella Helicobacter . Correlation analysis was negatively correlated concentration, had negative linear correlation both concentration. On other hand, positively TNF-α, These data demonstrated contributes decreasing hemorrhage inhibiting production inflammatory cytokines modulating microbiota.