Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report

• DOI: 10.3389/fimmu.2021.753558
• Publication Date: 2021-09-22T05:29:10Z
• Authors: Karen R. Sherwood; David D. M. Nicholl; Franz Fenninger; Vivian Wu; Paaksum Wong; Vince Benedicto; Davide P. Cina; Meng Wang; Taylor D. Pobran; Mari L. De Marco; Anna Citlali Márquez; Agatha N. Jassem; Inna Sekirov; Muhammad G. Morshed; Mohammad Bardi; Mypinder Sekhon; Paul Keown; Matthew Kadatz; James H. Lan
• Keywords: Immunosuppression; Basiliximab

To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where kidney recipient’s surgery coincided with positive SARS-CoV-2 test patient subsequently developed symptomatic perioperatively. We performed comprehensive immunological monitoring cellular, proteomic, serological changes during first 4 critical months post-infection. showed that continuation basiliximab induction maintenance triple immunosuppression did not significantly impair host’s ability to mount robust response against diagnosed within week