A Pan-Cancer Analysis of SMARCA4 Alterations in Human Cancers

• DOI: 10.3389/fimmu.2021.762598
• Publication Date: 2021-10-04T07:29:22Z
• Authors: Ling Peng; Jisheng Li; Jie Wu; Bin Xu; Zhiqiang Wang; Georgios Giamas; Justin Stebbing; Zhentao Yu
• Keywords: SMARCA4; Immune checkpoint; ARID1A

Background SMARCA4, the essential ATPase subunit of SWI/SNF chromatin remodeling complex, regulates transcription through control structure and is increasingly thought to play significant roles in human cancers. This study aims explore potential role SMARCA4 with a view providing insights on pathologic mechanisms implicated here. Methods The different tumors were explored based Cancer Genome Atlas (TCGA), Genotype-tissue expression (GTEx), Tumor Immune Estimation Resource (TIMER), Gene Set Enrichment Analysis (GSEA) datasets. difference, mutation phosphorylation status, survival, pathological stage, DNA methylation, tumor burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), microenvironment (TME), immune cell infiltration related analyzed. Results High levels observed most cancer types. samples correlates poor overall survival several Lung adenocarcinoma cases altered showed poorer prognosis. Enhanced S613, S695, S699, S1417 tumors, including breast cancer. correlated immunity associated cells genes TMB, MSI, MMR, methylation dysregulation was negatively CD8+ T-cell tumors. Furthermore, superfamily-type complex may be involved functional albeit these data require further confirmation. Conclusions Our offers comprehensive understanding oncogenic across correlate immunity.