Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life

• DOI: 10.3389/fimmu.2021.774433
• Publication Date: 2021-11-19T07:26:48Z
• Authors: Hanqi Lu; Yanting You; Xinghong Zhou; Qiuxing He; Ming Wang; Liqian Chen; Lin Zhou; Xiaomin Sun; Yanyan Liu; Pingping Jiang; Jiaojiao Dai; Xiuqiong Fu; Hiu Yee Kwan; Xiaoshan Zhao; Linjie Lou
• Keywords: Male; 0301 basic medicine; Citrus; Immunology; TMAO; Azithromycin; Diet, High-Fat; Mice; 03 medical and health sciences; Metabolic Diseases; early life; Animals; Chromatography, High Pressure Liquid; 2. Zero hunger; Citrus reticulata pericarpium extract; Plant Extracts; RC581-607; Glucose Tolerance Test; glycolipid metabolism disorder; Lipid Metabolism; Anti-Bacterial Agents; Disease Models, Animal; antibiotic exposure; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Disease Susceptibility; Immunologic diseases. Allergy; Glycolipids; Inflammation Mediators; Biomarkers

Studies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.The study investigated whether azithromycin (AZT) could promote high-fat diet (HFD)-induced Moreover, effect of citrus reticulata pericarpium (CRP) extract on via regulation microbiome exposed antibodies early life were investigated.Three-week-old treated with AZT (50 mg/kg/day) drinking water two weeks then fed a CRP (1% extract) four HFD five weeks. The results showed promoted HFD-induced disorder, increased levels inflammatory factors, flora product trimethylamine N-oxide (TMAO), induced microbial adult mice. Importantly, mitigated these effects.Taken together, findings suggest increases susceptibility mice, can decrease by regulating microbiome.