Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients

• DOI: 10.3389/fimmu.2021.777792
• Publication Date: 2022-01-03T06:14:25Z
• Authors: Thomas Weissmann; Michael Rückert; Jian-Guo Zhou; Michaela Seeling; Sebastian Lettmaier; Anna-Jasmina Dona...; Falk Nimmerjahn; Oliver J. Ott; Markus Hecht; Florian Putz; Rainer Fietkau; Benjamin Frey; Udo S. Gaipl; Lisa Deloch
• Keywords: Joint pain

Osteoarthritis (OA) is the leading degenerative joint disease in western world and leads, if left untreated, to a progressive deterioration of functionality, ultimately reducing quality life. Recent data has shown, that especially OA ankle foot are among most frequently affected regions. Current research points towards complex involvement various cell tissue types, often accompanied by inflammation. Low-dose radiotherapy (LDRT) widely used for treatment inflammatory diseases. While reported analgesic effects well known, underlying molecular mechanisms only poorly understood. We therefore correlated clinical approach, looking at pain reduction 196 patients treated with LDRT pre-clinical utilizing K/BxN serum transfer mouse model using flow cytometry multiplex ELISA analysis. an improvement symptoms majority was found, suffering from within tarsi transversa show significantly lower level improvement. Further, significant impact therapy success detected depending on whether one or both feet were affected. younger age showed better outcome than older ones while needing fewer series. When cellular model, systemic alteration immune cells namely shift CD8+ CD4+ T reduced numbers DCs observed. A general cytokines detected, alterations IL-4 IL-17 levels, all which could potentially be responsible highly effective patients. Taken together our indicate can regarded as option ankle, terms effects, Furthermore, observed mediated interplay soluble factors, model. With this interdisciplinary approach we aim encourage usage additive strategy not last resort, but also earlier course disease.