Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin

• DOI: 10.3389/fimmu.2022.1014924
• Publication Date: 2022-09-29T10:21:23Z
• Authors: Izumi Kishimoto; Ni Ma; Riko Takimoto-Ito; Chisa Nakashima; Atsushi Otsuka; Andrew F. Walls; Hideaki Tanizaki; Naotomo Kambe
• Keywords: Infiltration (HVAC); Oxazolone

A decrease in the number of basophils peripheral blood, or basopenia, has been noted, reflecting activity chronic spontaneous urticaria (CSU). Infiltration into skin also reported, but mechanism basopenia CSU not clarified. The phenomenon during active phase was confirmed, and basophil numbers increased following symptom improvement 15 out 17 patients treated with omalizumab 13 antihistamines. Our examination by immunostaining revealed infiltration lesions, as previous reports, since most our were already taking oral steroids, it considered appropriate to examine relationship between tissue blood. Then, we used mouse model contact hypersensitivity a single application oxazolone, which is known stimulate infiltration, investigated counts skin, bone marrow. In this model, blood observed one day after challenge, 2 days, supplementation from Indeed, when cultured expressing GFP transplanted GFP-positive remained low even days challenge. Despite differences among species models, these results suggest that reason for may involve migration circulating skin.