Comparing the B and T cell-mediated immune responses in patients with type 2 diabetes receiving mRNA or inactivated COVID-19 vaccines

• DOI: 10.3389/fimmu.2022.1018393
• Publication Date: 2022-10-11T08:30:20Z
• Authors: Chi-Ho Lee; Victor Gray; Jia Ming Nickolas...; Anthony Raymond Tam; Carol Ho-Yi Fong; David Tak-Wai Lui; Polly Pang; Kwok Hung Chan; Ivan Fan-Ngai Hung; Kathryn Choon-Ben...; Guang Sheng Ling
• Keywords: Immunity, Cellular; 0303 health sciences; COVID-19 Vaccines; SARS-CoV-2; Immunology; COVID-19; Viral Vaccines; RC581-607; 3. Good health; immunological memory response; 03 medical and health sciences; Diabetes Mellitus, Type 2; Immunoglobulin G; Humans; RNA, Viral; CoronaVac; BNT162b2; type 2 diabetes; RNA, Messenger; Immunologic diseases. Allergy; COVID-19 vaccine; BNT162 Vaccine

Acquiring protective immunity through vaccination is essential, especially for patients with type 2 diabetes who are vulnerable adverse clinical outcomes during coronavirus disease 2019 (COVID-19) infection. Type (T2D) associated immune dysfunction. Here, we evaluated the impact of T2D on immunological responses induced by mRNA (BNT162b2) and inactivated (CoronaVac) vaccines, two most commonly used COVID-19 vaccines. The study consisted parts. In Part 1, sera titres IgG antibodies against severe acute respiratory syndrome (SARS-CoV2) alpha receptor binding domain ( RBD), their neutralizing capacity, antigen-specific CD4 + T CD8 cell at 3-6 months after were compared between BNT162b2 (n=60) CoronaVac (n=50) vaccinees or without T2D. was a time-course investigating initial B among (n=16) Our data showed that impaired both cellular humoral CoronaVac. For BNT162b2, displayed reduction in T-helper 1 (Th1) differentiation following first dose. However, this defect rectified second dose resulting comparable levels memory cells, anti-RBD IgG, healthy individuals vaccination. Hence, influences effectiveness vaccines depending platform. findings provide potential mechanism susceptibility developing observed received either just one BNT162b2.