Integrated analysis from multi-center studies identities m7G-derived modification pattern and risk stratification system in skin cutaneous melanoma

• DOI: 10.3389/fimmu.2022.1034516
• Publication Date: 2022-12-01T15:04:16Z
• Authors: Xin Zhang; Ying Miao; Hao-Wen Sun; Yi-Xiao Wang; Wen-Min Zhao; A-Ying Pang; Xiao-Yan Wu; Cong-Cong Shen; Xiao-Dong Chen
• Keywords: 0303 health sciences; Skin Neoplasms; Immunology; immune microenvironment; skin cutaneous melanoma; RC581-607; Risk Assessment; 3. Good health; 03 medical and health sciences; Melanoma, Cutaneous Malignant; N7-methylguanosine; Tumor Microenvironment; Humans; prognosis; immunotherapy; Immunologic diseases. Allergy; Melanoma

The m7G modification has been proven to play an important role in RNA post-transcriptional and protein translation. However, the potential of patterns assessing prognosis Skin cutaneous melanoma (SKCM) tumor microenvironment (TME) not well studied. In this study, we investigated finally identified 21 available m7G-related genes. We used hierarchical clustering (K-means) classify 743 SKCM patients into three m7G-modified subtypes named m7G/gene cluster-A, B, C. found that both cluster B gene exhibited higher immune cell infiltration TME compared other subtypes. EIF4E3 IFIT5, two related genes, were markedly elevated Cluster B. Then, constructed score system utilizing principal component analysis (PCA) order evaluate patients' prognosis. High subtype was associated with better survival active response. Overall, article revealed involved development microenvironment. Evaluating will enhance our understanding characteristics help guide personal treatment clinics future.