Respiratory tract infections and risk factors for infection in a cohort of 330 patients with axial spondyloarthritis or psoriatic arthritis

• DOI: 10.3389/fimmu.2022.1040725
• Publication Date: 2022-10-26T09:21:32Z
• Authors: Natalie Frede; Eva Rieger; Raquel Lorenzetti; Alexandra Nieters; Ana C. Venhoff; Carolin Hentze; Marcus von Deimling; Nora Bartholomä; Jens Thiel; Reinhard E. Voll; Nils Venhoff
• Keywords: Axial spondyloarthritis; Respiratory tract

Respiratory tract infections (RTIs) are the most common in patients with rheumatic diseases under immunosuppressive treatment and may contribute to morbidity mortality as well increased healthcare costs. However, date only limited data on infection risk spondyloarthritis (SpA) available. In this study we assessed occurrence of respiratory a monocentric real-world cohort consisting 330 (168 psoriatic arthritis 162 axial patients) determined factors associated risk. Out SpA patients, 89.3% had suffered from ≥ 1 upper (URTI) 31.1% lower (LRTI) within last two years. The URTIs were rhinitis laryngitis/pharyngitis 87.3% 36.1%, respectively. Bronchitis constituted LRTI, reported 29.7% patients. multivariate binomial logistic regression model LRTI was chronic lung disease (OR 17.44, p=0.006), glucocorticoid therapy 9.24, p=0.012), previous history severe airway 6.82, p=0.013), number biological therapies 1.72, p=0.017), whereas HLA B27 positivity negatively 0.29, p=0.025). Female significantly more LRTIs than male (p=0.006) higher rate antibiotic (p=0.009). There no significant differences between axSpA PsA regarding frequency or use. 45.4% required antibiotics for infections. Antibiotic smoking 3.40, p=0.008), 3.38, p=0.004), sleep quality 1.13, p<0.001) age 0.96, p=0.030). Hypogammaglobulinemia (IgG<7g/l) rare (3.4%) despite continuous immunomodulatory treatment. Awareness these will assist physicians identify an risk, who benefit additional preventive measures, such vaccination cessation adjustment DMARD therapy.