IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study

• DOI: 10.3389/fimmu.2022.1060438
• Publication Date: 2023-01-05T18:20:34Z
• Authors: Maryam Shojaei; Amir Shamshirian; James Monkman; Laura Grice; Minh Tran; Chin Wee Tan; Siok Min Teo; Gustavo Rodrigues...; Timothy R. McCulloch; Marek Nalos; Maedeh Raei; Alireza Razavi; Roya Ghasemian; Mobina Gheibi; Fatemeh Roozbeh; Peter D. Sly; Kirsten M. Spann; Keng Yih Chew; Yanshan Zhu; Yao Xia; Timothy J. Wells; Alexandra Cristin...; Carmen Lúcia Kuni...; Claudio Luciano F...; Anna Flavia Ribei...; Lucia de Noronha; Sepideh Motamen; Reza Valadan; Omolbanin Amjadi; Rajan Gogna; Esha Madan; Reza Alizadeh-Navaei; Liliana Lamperti; Felipe Zuñiga; Estefania Nova-La...; Gonzalo Labarca; Ben Knippenberg; Velma Herwanto; Ya Wang; Amy Phu; Tracy Chew; Timothy Kwan; Karan Kim; Sally Teoh; Tiana M. Pelaia; Win Sen Kuan; Yvette Jee; Jon Iredell; Ken O’Byrne; John F. Fraser; Melissa J. Davis; Gabrielle T. Belz; Majid E. Warkiani; Carlos Salomon Gallo; Fernando Souza-Fo...; Quan Nguyen; Anthony Mclean; Arutha Kulasinghe; Kirsty R. Short; Benjamin Tang
• Keywords: Pandemic

Purpose Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate have been proposed COVID-19. However, at present, there is no consensus on the best diagnostic approach to in infected patients. Moreover, it not clear whether such tools would apply other potentially pandemic pathogens therefore of use as stockpile future preparedness. Methods We conducted a multi-cohort observational study investigate biology prognostic role interferon alpha-inducible protein 27 ( IFI27 ) Results show expressed respiratory tract elevated expression lower associated with presence high viral load. further demonstrate systemic host response, measured by blood expression, infection. For clinical outcome prediction (e.g., failure), displays sensitivity (0.95) specificity (0.83), outperforming known predictors outcomes. Furthermore, upregulated response viruses. example, H1N1/09 influenza virus infection, IFI27- like genes were highly samples severely Conclusion These data suggest targeting family could supplement conventional pandemics, independent pandemics caused coronavirus, an or another yet-to-be discovered virus.