BNT162b2 COVID-19 vaccination elicited protective robust immune responses in pediatric patients with inborn errors of metabolism

• DOI: 10.3389/fimmu.2022.1082192
• Publication Date: 2023-01-05T17:12:18Z
• Authors: Tanyel Zubarioglu; Harika Oyku Dinc; Duhan Hopurcuoglu; Ruveyda Gulmez; Esma Uygur; Gizem Yilmaz; Saffa Ahmadzada; Gozde Uzunyayla-Inci; Ece Oge-Enver; Ertugrul Kiykim; Bekir Kocazeybek; Cigdem Aktuglu-Ze...
• Keywords: 2019-20 coronavirus outbreak

Introduction SARS-CoV-2 infection can lead to a life-threatening acute metabolic decompensation in children with inborn errors of metabolism (IEM), so vaccination is mandatory. However, IEMs also impair innate or adaptive immunity, and the impact these immune system alterations on immunogenicity vaccine efficacy still unknown. Here, we investigated humoral responses BNT162b2 mRNA COVID-19 clinical outcomes pediatric IEM patients. Methods Fifteen patients between 12-18 years age confirmed diagnosis IEM, received were enrolled study. Patients an anti-SARS-CoV-2 IgG concentration >50 AU/mL before defined as “COVID-19 recovered” whereas undetectable naïve”. Anti-SARS-CoV-2 Immunoglobulin G (IgG) neutralizing antibody (nAb) titers measured assess response. Results nAb IH% increased significantly after first dose. The increase second remained significant naïve Complete seropositivity positivity was observed all Vaccination appears be clinically effective patients, none had within six months last vaccination. Discussion Humoral response two doses adequate not different from that healthy individuals.