Safety and efficacy of plasma exchange treatment in children with AQP4-IgG positive neuromyelitis optica spectrum disorder

• DOI: 10.3389/fimmu.2022.1113406
• Publication Date: 2023-01-05T15:44:22Z
• Authors: Zhichao Li; Lin Wan; Xinting Liu; Jing Wang; Xiuyu Shi; Huanfen Zhou; Quangang Xu; Shihui Wei; Guang Yang
• Keywords: Neuromyelitis Optica; Spectrum disorder; Optic neuritis; Acute disseminated encephalomyelitis

Neuromyelitis optica spectrum disorder (NMOSD), a severe demyelinating disease, is rare among children. Plasma exchange (PE) widely used as salvage therapy for and corticosteroid-unresponsive patients with NMOSD. Presently, there are limited studies on the safety efficacy of PE in children Herein, we report case six NMOSD who received along outcomes adverse events. All (female, age at onset 4 years 9 months–13 2 months) were AQP4-IgG positive standard using COM.TEC Cell Separator. The interval between was 29 days (range 10–98). Only one patient (P3) 10 after acute exacerbations exhibited clinical improvement. Her left visual acuity increased from 0.06 to 0.6 (spectacle-corrected 1.0) her EDSS score decreased 3 points. other five had no improvement scores changes PE. Adverse events included rashes (P1, P3), non-occlusive thrombosis internal jugular vein (P1), thrombocytopenia (P2). In conclusion, timing initiation rescue pediatric may be crucial treatment efficacy, early associated better outcome. Furthermore, has potential risk clinically significant effects that should considered before initiating weighed against benefits.