Gut Dysbiosis Is Associated With the Severity of Cryptogenic Stroke and Enhanced Systemic Inflammatory Response

• DOI: 10.3389/fimmu.2022.836820
• Publication Date: 2022-05-06T07:16:13Z
• Authors: Qianyi Zheng; Yongkang Chen; Yanping Zhai; Lin Meng; Han Liu; Haiyan Tian; Renyi Feng; Jiuqi Wang; Rui Zhang; Kedi Sun; Lina Gao; Yijing Wang; Xuejing Wang; Erxi Wu; Junfang Teng; Xuebing Ding
• Keywords: Dysbiosis; Stroke

Studies implicate that gut dysbiosis is related with many neurological diseases. However, the potential role of in cryptogenic stroke (CS) has not been elucidated yet. In this study, a high prevalence gastrointestinal (GI) dysfunction and inflammation increased intestinal permeability have found CS patients compared normal controls (NCs). The systemic was also identified by measuring levels plasma C-reactive protein (CRP), lipopolysaccharide (LPS), LPS-binding (LBP), white blood cells (WBC) count. Using 16S rRNA sequencing, we alpha diversity, accompanied higher abundance Enterobacteriaceae, Streptococcaceae, Lactobacillaceae at family level Escherichia–Shigella , Streptococcus Lactobacillus Klebsilla genus microbiota to NCs. Our results showed positively correlated inflammation, National Institutes Health Stroke Scale (NIHSS) scores, infarct volumes. conclusion, associated severity inflammation. Maintaining homeostasis may be strategy for treatment CS.