Association Between Endometriosis and Subsequent Risk of Sjögren’s Syndrome: A Nationwide Population-Based Cohort Study

• DOI: 10.3389/fimmu.2022.845944
• Publication Date: 2022-05-03T04:32:46Z
• Authors: Yung-Hsiang Chao; Chin-Hsiu Liu; Yu-An Pan; Fu-Shun Yen; Jeng-Yuan Chiou; James Cheng-Chung...
• Keywords: endometriosis; Adult; Immunology; Endometriosis; autoimmune disease; cohort; RC581-607; 3. Good health; Cohort Studies; Young Adult; 03 medical and health sciences; Sjogren's Syndrome; 0302 clinical medicine; Risk Factors; Immunology and Allergy; Sjogren’s syndrome; Humans; epidemiology; Female; Immunologic diseases. Allergy; Retrospective Studies

The relationship between endometriosis and the ensuing risk of Sjögren's syndrome has remained unclear. This study aims to present epidemiological evidence for this connection. is a retrospective cohort patients (ICD-9-CM 617.0-617.9 621.3) matched comparison group 2000 2012 in National Taiwan Insurance Research Database. After age matching, we analyzed association 710.2). We used Cox proportional hazard model examine ratio incidental syndrome. Subgroup analyses on age, comorbidities, disease duration were also performed. A total 73,665 individuals included study. identified 14733 newly diagnosed 58,932 non-endometriosis group. adjusted (HR) was 1.45 (95% confidence interval CI=1.27-1.65) group, compared In subgroup analysis, HR 1.53 CI=1.25-1.88) 20-39 1.41 CI =1.18-1.68) 40-64. Time-vary analysis showed that who have follow-up time fewer than five years (adjusted HR=1.57, 95% CI=1.32-1.87) significantly highest having subsequent population-based indicated history puts at an increased getting afterward, especially within first after diagnosis endometriosis. Clinicians should recognize possible managing or patients.