Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine

• DOI: 10.3389/fimmu.2022.848961
• Publication Date: 2022-05-24T11:05:57Z
• Authors: Yi Wang; Xiaoxia Wang; Laurence Don Wai Luu; Shaojin Chen; Fu Jin; Shufang Wang; Xiaolan Huang; Licheng Wang; Xiaocui Zhou; Xi Chen; Xiaodai Cui; Jieqiong Li; Jun Tai; Xiong Zhu
• Keywords: Humoral immunity

CoronaVac (Sinovac), an inactivated vaccine for SARS-CoV-2, has been widely used immunization. However, analysis of the underlying molecular mechanisms driving CoronaVac-induced immunity is still limited. Here, we applied a systems biology approach to understand behind adaptive immune response in cohort 50 volunteers immunized with 2 doses CoronaVac. Vaccination led integrated that included several effector arms system including specific IgM/IgG, humoral and other response, as well innate shown by complement activation. Metabolites associated were also identified implicating role metabolites activation response. Networks TCA cycle amino acids metabolic pathways, such phenylalanine metabolism, phenylalanine, tyrosine tryptophan biosynthesis, glycine, serine threonine metabolism tightly coupled immunity. Critically, constructed multifactorial network (MRN) analyze interactions compared signatures affected immunization SARS-CoV-2 infection further identify related pathways altered These results help us host vaccination highlight utility defining correlates protection vaccination.