Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis

• DOI: 10.3389/fimmu.2022.863753
• Publication Date: 2022-05-04T07:19:53Z
• Authors: Rui Zhang; Jinlin Miao; Kui Zhang; Bei Zhang; Xing Luo; Haoyang Sun; Zhaohui Zheng; Ping Zhu
• Keywords: Erythrocyte sedimentation rate; Treg cell; Regulatory T cell

Objectives This study aimed to investigate the changes in quantity and function of T helper (Th)-like regulatory (Treg) cell subsets peripheral blood (PB) synovial fluid (SF) rheumatoid arthritis (RA) patients understand their relationship with disease activity. Methods A total 86 RA 76 gender age-matched healthy controls (HC) were enrolled this study. Th-like Treg frequency determined using flow cytometry. The inhibitory cells was detected an vitro co-culture suppression assay. Results proportion absolute number Th1-like from PB SF significantly higher than those HC PB. In SF, proportions lower elevated erythrocyte sedimentation rate or C-Reactive Protein group, positive groups anti-CCP antibody anti-MCV antibody. Additionally, negatively correlated However, expression levels CD73 TGF-β1 decreased, these could not effectively inhibit proliferation effector (Teff) cells. Conclusion Our data indicate that are predominant subset but suppressive is defective. Improving may control inflammation joints provide new strategies for Treg-targeted therapies RA.