The pyroptosis-related gene signature predicts prognosis and indicates the immune microenvironment status of chronic lymphocytic leukemia

• DOI: 10.3389/fimmu.2022.939978
• Publication Date: 2022-09-13T04:37:55Z
• Authors: Yeqin Sha; Rui Jiang; Yi Miao; Shuchao Qin; Wei Wu; Yi Xia; Li Wang; Lei Fan; Hui Jin; Wei Xu; Jianyong Li; Huayuan Zhu
• Keywords: Pyroptosis; KEGG

Chronic lymphocytic leukemia (CLL) is the most common in Western world with great heterogeneity. Pyroptosis has recently been recognized as an inflammatory form of programmed cell death (PCD) and shares a close relationship apoptosis. Although role apoptosis CLL was comprehensively studied successfully applied clinical treatment, between pyroptosis genes remained largely unknown. In this study, eight differentially expressed pyroptosis-related (PRGs) were identified normal B cells. order to screen out prognostic value PRGs, univariate multivariate Cox regression analyses conducted risk model three PRG signatures (GSDME, NLRP3, PLCG1) constructed. All samples stratified into high- low-risk subgroups according scores. The showed high efficacy predicting both overall survival (OS) time first treatment (TTFT). Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Set Enrichment Analysis (GSEA) dysregulation immune response high-risk group. Single-sample GSEA (ssGSEA) infiltration activity immune-related pathways also displayed decreased antitumor immunity conclusion, PRGs are may play important roles tumor immunity, underlying needs be explored further.