Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19

• DOI: 10.3389/fimmu.2022.945603
• Publication Date: 2022-07-29T14:35:05Z
• Authors: Felix Schagatay; Klara Diamant; Mats Lidén; Alicia Edin; Simon Athlin; Olof Hultgren; Clas Ahlm; Mattias N. E. For...; Johanna Savilampi; Johan Normark; Anna Lange; Sara Cajander
• Keywords: Pathogenesis

Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads severe COVID-19. Cold-inducible RNA-binding protein (CIRP), newly identified DAMP aggravates inflammation and tissue injury, induces respiratory failure in sepsis. Whether CIRP contributes pathogenesis COVID-19 has not yet been explored. Aim To investigate if concentration extracellular (eCIRP) serum associates with lung involvement by chest computed tomography (CT) Methods Herein we report prospective observational study patients included at two University Hospitals Sweden between April 2020 May 2021. Serum from hospitalized Örebro (N=97) were used assess association eCIRP level support its correlation pulmonary on CT inflammatory biomarkers. A cohort non-hospitalized Umeå (N=78) was as an external validation cohort. The severity disease defined according highest degree support; mild (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO <50% FiO2), (HFNO ≥50% FiO2, mechanical ventilation). Unadjusted adjusted linear regression evaluate peak day 0-4 respect severity, age, sex, Charlson comorbidity score, symptom duration, BMI. Results Peak concentrations higher independently associated both cohorts (Örebro; p =0.01, Umeå; <0.01). measured correlated eCIRP, r s =0.30, <0.01 (n=97). Conclusion High levels are acute Experimental studies needed determine treatments targeting reduces risk