NCAPG2 could be an immunological and prognostic biomarker: From pan-cancer analysis to pancreatic cancer validation

• DOI: 10.3389/fimmu.2023.1097403
• Publication Date: 2023-01-27T04:40:12Z
• Authors: Qi Wang; Zhangzuo Li; Shujing Zhou; Zhengrui Li; Xufeng Huang; Yiwei He; Yuhan Zhang; Xiaoxian Zhao; Yidan Tang; Min Xu
• Keywords: 0301 basic medicine; immune infiltration; Carcinogenesis; Chromosomal Proteins, Non-Histone; pancreatic cancer; Immunology; pan-cancer; Oncogenes; RC581-607; Prognosis; immunity; 3. Good health; Pancreatic Neoplasms; 03 medical and health sciences; NCAPG2; biomarker; Humans; Immunologic diseases. Allergy

More recently, NCAPG2 has emerged as an intrinsically essential participant of the condensin II complex involved in process chromosome cohesion and stabilization mitosis, its position particular tumours is now being highlighted. Simultaneously, genetic properties hint that it might have enormous potential to interpret malignant progression tumors a broader perspective, is, pan-cancer. Yet, at present, this recognition remains merely superficial there lack more detailed studies explore underlying pathogenesis. To meet need, current study was undertaken comprehensively elucidate functions pan-cancer, based on combination existing databases like TCGA GTEx. identified be overexpressed almost every tumor exhibit significant prognostic diagnostic efficacy. Furthermore, correlation between selected immune features, namely cell infiltration, checkpoint genes, TMB, MSI, etc. also indicates could potentially applied guidance immunotherapy. Subsequently, pancreatic cancer, further clarified utility downregulation expression result reduced proliferation, invasion metastasis cancer cells, among such phenotypical changes, epithelial-mesenchymal transition disruption least one possible mechanisms raising or enhancing tumorigenesis. Taken above, NCAPG2, member pan-oncogenes, would serve biomarker therapeutic target for range malignancies, sharing new insights into precision medicine.