Labour promotes systemic mobilisation of monocytes, T cell activation and local secretion of chemotactic factors in the intervillous space of the placenta

• DOI: 10.3389/fimmu.2023.1129261
• Publication Date: 2023-03-08T04:44:35Z
• Authors: Sara Vikberg; Robert Lindau; Martin Solders; Johanna Raffetseder; Snehil Budhwar; Jan Ernerudh; Eleonor Tiblad; Helen Kaipe
• Keywords: Intervillous space; Monocyte; Decidua; Trophoblast

During pregnancy, maternal blood circulates through the intervillous space of placenta and reciprocal interactions between foetal tissues immune cells makes a unique immunological niche. Labour is characterised by proinflammatory response in myometrium, but relationship local systemic changes during onset labour remains elusive. We here aimed to investigate how circulatory systems are affected from an point view. report that proportion monocytes dramatically higher peripheral (PB), (IVB) decidua labouring (n = 14) compared non-labouring women 15), suggesting leads both mobilisation monocytes. was associated with relative increase effector memory T periphery, MAIT showed elevated expression activation markers PB IVB. Intervillous consisted degree CD14 + CD16 intermediate monocytes, independently mode delivery, displayed altered phenotypic pattern. A proximity extension assay analysis 168 proteins revealed several myeloid cell migration function, including CCL2 M-CSF, were upregulated IVB plasma women. Thus, could be bridging site for communication which contribute monocyte generation inflammatory reactions spontaneous labour.