Ferroptosis: an important player in the inflammatory response in diabetic nephropathy

• DOI: 10.3389/fimmu.2023.1294317
• Publication Date: 2023-12-04T04:38:46Z
• Authors: Jialing Li; Luxin Li; Zhen Zhang; Peijian Chen; Haiying Shu; Can Yang; Yanhui Chu; Jieting Liu
• Keywords: Pathogenesis

Diabetic nephropathy (DN) is a chronic inflammatory disease that affects millions of diabetic patients worldwide. The key to treating DN early diagnosis and prevention. Once the patient enters clinical proteinuria stage, renal damage difficult reverse. Therefore, developing treatment methods critical. pathogenesis results from various factors, among which immune response inflammation play major roles. Ferroptosis newly discovered type programmed cell death characterized by iron-dependent lipid peroxidation excessive ROS production. Recent studies have demonstrated activation closely related occurrence development ferroptosis. Moreover, hyperglycemia induces iron overload, peroxidation, oxidative stress, inflammation, fibrosis, all are pathogenesis, indicating ferroptosis plays role in DN. this review focuses on regulatory mechanisms ferroptosis, mutual processes involved inflammation. By discussing analyzing relationship between DN, we can deepen our understanding develop new therapeutics targeting or inflammation-related for with