Metabolic changes with the occurrence of atherosclerotic plaques and the effects of statins

• DOI: 10.3389/fimmu.2023.1301051
• Publication Date: 2023-12-08T12:28:36Z
• Authors: Lingmin Zhao; Di Ma; LiJuan Wang; XingQi Su; LiangShu Feng; LiChong Zhu; Ying Chen; YuLei Hao; XinYu Wang; JiaChun Feng
• Keywords: Foam cell; Fibrous cap; Proinflammatory cytokine

Atherosclerosis is a common cardiovascular disease caused by the abnormal expression of multiple factors and genes influenced both environmental genetic factors. The primary manifestation atherosclerosis plaque formation, which occurs when inflammatory cells consume excess lipids, affecting their retention modification within arterial intima. This triggers endothelial cell (EC) activation, immune infiltration, vascular smooth muscle (VSMC) proliferation migration, foam lipid streaks, fibrous development. These processes can lead to wall sclerosis, lumen stenosis, thrombosis. Immune cells, ECs, VSMCs in atherosclerotic plaques undergo significant metabolic changes responses. interaction cytokines chemokines secreted these leads onset, progression, regression atherosclerosis. regulation cell- or cytokine-based responses novel therapeutic approach for Statins are currently pharmacological agents utilised managing unstable owing ability enhance function, regulate VSMC apoptosis reducing cholesterol levels, mitigate activity cytokines. In this review, we provide an overview associated with atherosclerosis, describe effects on plaques, discuss mechanisms through statins contribute stabilisation. Additionally, examine role combination other drugs management