Roles of inflammatory cell infiltrate in periprosthetic osteolysis

• DOI: 10.3389/fimmu.2023.1310262
• Publication Date: 2023-12-01T17:45:20Z
• Authors: Isidora Panez-Toro; Dominique Heymann; François Gouin; Jérôme Amiaud; Marie-Françoise H...; Luis A. Córdova
• Keywords: Osteolysis; CD68

Classically, particle-induced periprosthetic osteolysis at the implant–bone interface has explained aseptic loosening of joint replacement. This response is preceded by triggering both innate and acquired immune with subsequent activation osteoclasts, bone-resorbing cells. Although been considered a foreign body chronic inflammation mediated myelomonocytic-derived cells, current reports describe wide heterogeneous inflammatory cells infiltrating tissues. review aims to discuss role those non-myelomonocytic in tissues exposed wear particles showing original data. Specifically, we T (CD3 + , CD4 CD8 ) B (CD20 coexisting CD68 /TRAP − multinucleated giant associated polyethylene metallic retrieved membranes. contributes valuable insight support complex cell molecular mechanisms behind theories orthopedic implants.