Inflammatory bowel disease activity threatens ankylosing spondylitis: implications from Mendelian randomization combined with transcriptome analysis

• DOI: 10.3389/fimmu.2024.1289049
• Publication Date: 2024-02-28T04:29:23Z
• Authors: Yimei Ding; Jiaxu Chen; Rouxin Li; Luan Xue
• Keywords: Mendelian Randomization

Background Inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) share common traits of chronic recurrent inflammation affecting both the intestines joints. Epidemiological studies have revealed that incidence AS has jumped from 0.3% to 3% among patients with IBD. However, these findings do not definitively establish a causal relationship whereby IBD directly leads development AS. Moreover, whether activity will an impact on this process remains pending question. Methods Two-sample Mendelian randomization (MR) analyses were employed across multiple datasets investigate potential as risk factor for The pathogenic genes identified by MR analysis expression quantitative trait locus. Risk scores active inactive calculated single-sample gene set enrichment analysis. Comparative assessments encompassing alterations in transcription activity, shifts signaling pathways, variances immune cell profiles conducted between patients. correlation cells was quantified. Results A total 6 analyses, 3 exposure 2 outcome datasets, consistently substantially elevates development. two 66 54 genes, respectively. Notably, computed distinct sets notably higher compared their counterparts. Discernible variations risk-associated factors observed In addition, three inflammatory pathways exhibited marked activation seven specific types, closely linked statistically significant correlations genes. Conclusion By combining transcriptome analysis, study postulates AS, further presents innovative evidence progression