Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

• DOI: 10.3389/fimmu.2024.1334828
• Publication Date: 2024-01-29T04:40:10Z
• Authors: Chunjia Zhang; Yan Li; Yan Yu; Zehui Li; Xin Xu; Zuliyaer Talifu; Wubo Liu; Degang Yang; Feng Gao; Song Wei; Liang Zhang; Han Gong; Run Peng; Liangjie Du; Jianjun Li
• Keywords: Regulatory T cell

Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic pain. During the initial stages following spinal injury, inflammation plays critical role; however, excessive exacerbate Regulatory T cells (Treg cells) have crucial function in regulating and alleviating Treg release suppressor cytokines modulate of other immune suppress inflammatory response. Simultaneously, impedes cell activity, further intensifying Therefore, suppressing response while enhancing regulatory may provide novel therapeutic avenues for treating pain resulting from injury. This review comprehensively describes mechanisms underlying regulation subsequent with specific focus on exploring potential through which regulate The insights gained this aim new concepts rationale prospects direction therapy injury-related conditions.