Facial palsy after administration of immune checkpoint inhibitors: case report, literature review and clinical care management

• DOI: 10.3389/fimmu.2024.1375497
• Publication Date: 2024-03-22T04:29:45Z
• Authors: Essia Mezni; Giovanni Corazza; Roxane Mari; Stephanie Coze; Nathalie Charrier; Brice Chanez; Anne Sophie Chretien; Philippe Rochigneux
• Keywords: Temozolomide

Neurological immune-related adverse events (irAEs) due to immune checkpoint inhibitors (ICI) are rare complications of immunotherapy, particularly dreadful for patients and clinical teams. Indeed, neurological irAEs potentially severe their diagnosis require prompt recognition treatment. Additionally, the spectrum is broad, affecting either neuromuscular junction, peripheral or central nervous system. Here, we described case a 55-year man with metastatic melanoma, facing brutal right cerebral palsy after his third ipilimumab/nivolumab infusion. After presentation, reviewed literature about this complication its work-up management.