Non-cross-reactive epitopes dominate the humoral immune response to COVID-19 vaccination – kinetics of plasma antibodies, plasmablasts and memory B cells

• DOI: 10.3389/fimmu.2024.1382911
• Publication Date: 2024-05-14T04:48:47Z
• Authors: Kilian A. Wietschel; Kevin Fechtner; Elmer Antileo; Goran Abdurrahman; Chiara A. Drechsler; Michelle Kudzayi ...; Ruben Rose; Mathias Voß; Andi Krumbholz; Stephan Michalik; Stefan Weiss; Lena Ulm; Philipp Franikowski; Helmut Fickenscher; Barbara M. Bröker; Dina Raafat; Silva Holtfreter
• Keywords: Memory B cell; Convalescent plasma

COVID-19 vaccines are highly effective in inducing protective immunity. While the serum antibody response to vaccination has been studied depth, our knowledge of underlying plasmablast and memory B cell (Bmem) responses is still incomplete. Here, we determined a naïve population contrasted it with single influenza primed cohort. In addition, analyzed against four endemic human coronaviruses (HCoVs).