Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis

• DOI: 10.3389/fimmu.2024.1489077
• Publication Date: 2025-01-07T05:27:26Z
• Authors: Zeli Tang; Caibiao Wei; Xueling Deng; Qiumei Lin; Qiping Hu; Shitao Li; Jilong Wang; Yuhong Wu; Dengyu Liu; Min Fang; Tingzheng Zhan
• Keywords: Clonorchis sinensis; Clonorchiasis

Clonorchis sinensis (C. sinensis) infection is a significant risk factor for hepatocellular carcinoma (HCC), yet its underlying mechanisms remain poorly understood. This study aimed to investigate the impact of C. on serum proteomic and metabolomic profiling HCC patients, focusing potential mechanisms. A retrospective clinical analysis was conducted 1121 comparing those with without infection. The influence proteome metabolome in further assessed. correlated younger age at cancer onset, male predominance, advanced stage, liver cirrhosis, microvascular invasion patients. It also associated shorter overall survival (OS) recurrence-free (RFS). levels blood lipids (e.g., APO-A, HDL-C, TG) were significantly altered after Proteomic analyses revealed metabolic reprogramming caused by sinensis, excessive depletion argininosuccinate synthase (ASS) D-glucose as factors sinensis-associated malignancy. Key molecules ILF2, CNN2, OLFM4, NOTCH3, LysoPA implicated progression. Furthermore, triggered inflammation, insulin resistance, pro-tumor immune escape, exacerbated complication degenerative diseases. not only provides compelling evidence elucidating sinensis-mediated development but identifies therapeutic targets patients co-infected sinensis.