Association of C1QTNF6 gene polymorphism with risk and clinical features of type 1 diabetes in Chinese: implications for ZnT8A and beta-cell function

• DOI: 10.3389/fimmu.2025.1551552
• Publication Date: 2025-04-09T05:20:50Z
• Authors: Jinhan Liu; Ying Xia; Zhiguo Xie; Xia Li; Gan Huang; Jingyi Hu; Zhiguang Zhou

Genome-wide association study identified C1QTNF6 as a candidate gene for type 1 diabetes (T1D) in Caucasians. We aimed to investigate if rs229541 conferred susceptibility T1D Chinese, independent of DR-DQ genotypes and this polymorphism affected the clinical profiles T1D. In case-control study, were obtained from 1278 patients with 1282 nondiabetic controls using MassARRAY. Genotypic (P = 0.0210) allelic 0.0084) frequencies significantly different between group control group. When model was adjusted genotypes, G allele carriers observed less often 0.0423, OR 0.82, 95% CI 0.68-0.99) than group, associated reduced risk(P 0.0167, 0.83, 0.71-0.97). who homozygous showed higher positive rate ZnT8A A 0.0171, 1.88, 1.12-3.16). By detection fasting C-peptide, exhibited lower frequency beta-cell failure compared those A/A genotype 0.0058, 0.70, 0.54-0.90). not found be correlated GADA, IA-2A or age at diagnosis. The independently risk Chinese broadly modified features disease. This loci might utilized construct genetic combination well-known region future screening genetically prone individuals among Chinese.