Case Report: A novel chemotherapy-free regimen combined with photodynamic therapy, target therapy, and immunotherapy in a geriatric male with huge recurrent scalp and facial angiosarcoma: a report of an extremely rare case and literature review

• DOI: 10.3389/fimmu.2025.1556493
• Publication Date: 2025-04-29T05:26:06Z
• Authors: Ewetse Paul Maswi...; Zedong Feng; Zhenyu Yin; Fan Zhang; Lijuan He; Baohong Gu; Lin Xiang; Huixia Li; Caijuan Wang; Yang Yu; Bo Xu; Jize Wang; Hao Chen
• Keywords: Regimen

Angiosarcomas are sporadic vascular neoplasms among the most aggressive subtypes of soft tissue sarcomas. In addition, vast and multiple recurrent superficial scalp facial angiosarcomas very complex extremely difficult to manage. Their occurrence brings about significant social emotional distress affected individuals. To date, no specific therapeutic strategy has been effective reliable. Herein, we report a highly unique case geriatric male patient with angiosarcoma successfully treated by chemotherapy-free regimen consisting photodynamic therapy (PDT), immunotherapy, target therapy. Notably, PDT provided promising remarkable auspicious outcomes proved be better option for refractory malignant angiosarcomas.