Diagnosis of Fibrosis Using Blood Markers and Logistic Regression in Southeast Asian Patients With Non-alcoholic Fatty Liver Disease

• DOI: 10.3389/fmed.2021.637652
• Publication Date: 2021-02-23T06:36:26Z
• Authors: Chao Sang; Hongmei Yan; Wah Kheong Chan; Xiaopeng Zhu; Tao Sun; Xinxia Chang; Mingfeng Xia; Xiaoyang Sun; Xiqi Hu; Xin Gao; Wei Jia; Hua Bian; Tianlu Chen; Guoxiang Xie
• Keywords: Gold standard (test); Aspartate transaminase

Non-alcoholic fatty liver disease (NAFLD) is one of the main causes fibrosis. Liver biopsy remains gold standard for confirmation fibrosis in NAFLD patients. Effective and non-invasive diagnosis advanced essential to surveillance treatment decisions. Herein we used routine medical test markers logistic regression differentiate early patients from China, Malaysia, India ( n 1 = 540, 2 147, 3 97) who were confirmed by biopsy. Nine parameters, including age, body mass index, fasting blood glucose, presence diabetes or impaired glycemia, alanine aminotransferase, γ-glutamyl transferase, triglyceride, aspartate transaminase/platelet count ratio, selected stepwise regression, receiver operating characteristic curve (ROC), hypothesis testing model construction. The area under ROC (auROC) was 0.82 differentiating (sensitivity 0.69, when specificity 0.80) discovery set. Its diagnostic ability remained good two independent validation sets (auROC 0.89 0.71) consistently superior existing panels such as FIB-4 score. A web-based tool, LiveFbr, developed fast access our model. new may serve an attractive tool classification