Identification of Senescence-Related Subtypes, the Development of a Prognosis Model, and Characterization of Immune Infiltration and Gut Microbiota in Colorectal Cancer

• DOI: 10.3389/fmed.2022.916565
• Publication Date: 2022-06-01T14:45:54Z
• Authors: Ju-Ji Dai; Yang-Yang Fu; Xi-Qiang Zhong; Wei Cen; Mao-Fei Ye; Xi-Han Chen; Yi-Fei Pan; Le-Chi Ye
• Keywords: Senescence

Cellular senescence is associated with tumorigenesis, and the subtype prognostic signatures of senescence-related genes (SRGs) in tumor microenvironment (TME) gut microbiota have not been fully determined. Analysis 91 SRGs obtained from GSEA MSigDB, mRNA sequencing Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases enabled identification two distinct molecular types colorectal cancer (CRC). Patient samples were clustered into subtypes, Kaplan-Meier survival analyses showing significant differences patient between subtypes. Cluster C2 was clinicopathological features, high immune score, abundance infiltrating cells somewhat bacteria. A risk model based on eight showed that a low score characterized by inhibition activity indicative better prognosis patients CRC. In combination clinical characteristics, found to be an independent predictor conclusion, present study subtypes signature consisting CRC prognosis, as well cell infiltration microbiota. These findings may enable prediction facilitate individualized treatments.