Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy

• DOI: 10.3389/fmed.2023.1251851
• Publication Date: 2023-10-04T09:22:29Z
• Authors: Neslihan Cabioglu; Cihan Uras; Halime Mutlu; Derya Sezgin; Selman Emiroglu; Onur Dulgeroglu; Ravza Yilmaz; Mustafa Tukenmez; Akif Enes Arikan; Halil Kara; Mahmut Muslumanoglu
• Keywords: Therapeutic effect; Granulomatous Mastitis

Intralesional steroid injection has recently evolved as a novel treatment modality for localized idiopathic granulomatous mastitis (= IGM). We aimed to explore the therapeutic efficacy of local injections (LSI) in patients with severe IGM.Fifty-one diagnosed IGM were included study and treated either alone (n = 25) or combined LSI systemic oral (OST) 26). The protocol an intralesional triamcinolone acetonide into palpable granulomas every 4-week, topical administration steroid-containing pomades twice day on affected surface breast. Patients OST received low-dose methylprednisolone (<16 mg).Patients required more applications than those group (LSI: 5 ± 2.9; vs. LSI/OST: 3.5 2.5; p 0.080) obtain effective optimum response. At median 12 months (range, 4-42), no difference was found complete response rates between (52 53.9%, 0.999). However, steroid-related side effects lower (p < 0.008).Local could be considered first-line until been obtained sole steroids. Compared therapy, can new fewer effects.