Advancements in elucidating the pathogenesis of actinic keratosis: present state and future prospects

• DOI: 10.3389/fmed.2024.1330491
• Publication Date: 2024-03-19T04:35:54Z
• Authors: Zhongzhi Wang; Xiaolie Wang; Yuanyang Shi; Siyu Wu; Yu Ding; Guotai Yao; Jianghan Chen
• Keywords: Actinic keratosis; Pathogenesis; Epidermodysplasia verruciformis; Keratosis

Solar keratosis, also known as actinic keratosis (AK), is becoming increasingly prevalent. It a benign tumor that develops in the epidermis. Individuals with AK typically exhibit irregular, red, scaly bumps or patches result of prolonged exposure to UV rays. These growths primarily appear on sun-exposed areas skin such face, scalp, and hands. Presently, dermatologists are actively studying due its rising incidence rate United States. However, underlying causes remain poorly understood. Previous research has indicated onset involves various mechanisms including ray-induced inflammation, oxidative stress, complex mutagenesis, resulting immunosuppression, inhibited apoptosis, dysregulated cell cycle, altered proliferation, tissue remodeling, human papillomavirus (HPV) infection. can develop three ways: spontaneous regression, persistence, progression into invasive cutaneous squamous carcinoma (cSCC). Multiple risk factors diverse signaling pathways collectively contribute pathogenesis. To mitigate cancerous changes associated long-term radiation exposure, prompt identification, management, prevention crucial. The objective this review elucidate primary malignancy identify potential treatment targets for clinical settings.