Lactobacillus mucosae exerted different antiviral effects on respiratory syncytial virus infection in mice

• DOI: 10.3389/fmicb.2022.1001313
• Publication Date: 2022-08-26T09:24:06Z
• Authors: Qianwen Wang; Zhifeng Fang; Lingzhi Li; Hongchao Wang; Jinlin Zhu; Pinghu Zhang; Yuan-kun Lee; Jianxin Zhao; Hao Zhang; Wenwei Lu; Wei Chen
• Keywords: Akkermansia muciniphila

Respiratory syncytial virus (RSV) infection is a constant threat to the health of young children, and this mainly attributed lack effective prevention strategies. This study aimed determine whether Lactobacillus (L.) mucosae, potential probiotic, could protect against respiratory viral in mouse model. Naive 3-4-week-old BALB/c mice were orally administered with three L. mucosae strains (2.5 × 108 CFU/mouse) 7 days before RSV (105 TCID50/mouse). Results showed that all inhibited replication reduced proportions inflammatory cells, including granulocytes monocytes blood. The M104R01L3 treatment maintained stable weight increased interferon (IFN)-β tumor necrosis factor (TNF)-α levels. DCC1HL5 interleukin (IL)-1β IL-10 Moreover, Akkermansia, Alistipes, Anaeroplasma which contributed advantageous modulation gut microbiota. Besides, affected levels short-chain fatty acids (SCFAs) are important for antiviral response. 1,025 acetate, propionate, butyrate levels, whereas level acetate gut. may by upregulating IFN-β lungs its effect be related increase In conclusion, exerted effects differentially regulating immune responses intestinal micro-ecological balance. can provide reference studying mechanisms underlying mucosae.