Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil

• DOI: 10.3389/fmicb.2022.799713
• Publication Date: 2022-02-07T06:36:41Z
• Authors: Ana Valesca Ferna...; Diego Menezes; Filipe Romero Reb...; Octávio Alcântara...; Paula Luize Camar...; Rennan Garcias Mo...; Hugo José Alves; Vivian Ribeiro Alves; Tânia Maria de Re...; Adriano Neves Coelho; Júlia Maria Sarai...; Augusto Viana da ...; Luiz Gonzaga Paul...; João Locke Ferrei...; Hilton Soares de ...; Nova Jersey Cláud...; Camila Zolini; Jôsy Hubner de Sousa; Elizângela Gonçal...; Rafael Marques de...; Luciana de Lima F...; Alexandra Lehmkuh...; Ana Paula de Camp...; Paulo Henrique Si...; Fernanda Martins ...; Lucyene Miguita; Cristiane Campos ...; Tuffi Saliba Neto; Fabrícia Soares F...; Daniel Costa Queiroz; Damares Nigia Alb...; Luciana Cunha Res...; Franciele Martins...; Erika Fernanda Ca...; Carolina Moreira ...; Ana Tereza Vascon...; Renato Santana de...; Renan Pedra de Souza
• Keywords: Seroprevalence; Pandemic; Odds

The COVID-19 pandemic has created an unprecedented need for epidemiological monitoring using diverse strategies. We conducted a project combining prevalence, seroprevalence, and genomic surveillance approaches to describe the initial stages in Betim City, Brazil. collected 3239 subjects population-based age-, sex- neighborhood-stratified, household, prospective; cross-sectional study divided into three surveys 21 days apart sampling same geographical area. In first survey, overall prevalence (participants positive serological or molecular tests) reached 0.46% (90% CI 0.12-0.80%), followed by 2.69% 1.88-3.49%) second survey 6.67% 5.42-7.92%) third. underreporting 11, 19.6, 20.4 times each survey. observed increased odds test females compared males (OR 1.88 95% 1.25-2.82), while single best predictor positivity was ageusia/anosmia 8.12, 4.72-13.98). Thirty-five SARS-CoV-2 genomes were sequenced, of which 18 classified as lineage B.1.1.28, 17 B.1.1.33. Multiple independent viral introductions observed. Integration multiple strategies able adequately dispersion city. Presented results have helped local government authorities guide management.