2,5-Diketopiperazines From a Sponge-Derived Fungus Aspergillus sclerotiorum

• DOI: 10.3389/fmicb.2022.808532
• Publication Date: 2022-05-20T09:13:35Z
• Authors: Chao-Yi Wang; Xiao-Han Liu; Yao-Yao Zheng; Xing-Yan Ning; Ya-Hui Zhang; Xiu-Mei Fu; Xin Li; Chang-Lun Shao; Chang-Yun Wang
• Keywords: Diketopiperazines; Sponge

Three new 2,5-diketopiperazines, speramide C ( 1 ), 3,21- epi -taichunamide F 2 and 2- -amoenamide 3 along with four known analogs 4 – 7 were obtained from the sponge-derived fungus Aspergillus sclerotiorum GDST-2013-0501 collected South China Sea. The chemical structures of compounds elucidated by analyzing NMR MS spectroscopy data, their absolute configurations determined electronic circular dichroism (ECD) calculations. Compound represents first prenylated indole alkaloid an ethylene oxide ring at isopentenyl side chain. displayed DNA topoisomerase I inhibitory activity antibacterial against Staphylococcus epidermidis . low cytotoxic or non-cytotoxic compound activity, which could provide a starting point for development antitumor agents.