Impacts of Nontuberculous Mycobacteria Isolates in Non-cystic Fibrosis Bronchiectasis: A 16-Year Cohort Study in Taiwan

• DOI: 10.3389/fmicb.2022.868435
• Publication Date: 2022-04-18T05:20:49Z
• Authors: Chun-Yu Lin; Hung-Yu Huang; Meng-Heng Hsieh; Yueh-Fu Fang; Yu-Lun Lo; Shu-Min Lin; Yu-Tung Huang; Chih-Hsin Yeh; Chun-Hua Wang; Horng-Chyuan Lin
• Keywords: Nontuberculous Mycobacteria

The prevalence of nontuberculous mycobacteria (NTM) in patients with chronic respiratory disease has increased. implication NTM non-CF bronchiectasis remained controversial. This study investigated the impact Taiwan. Clinical manifestation, imaging, and microbiological data were retrieved from Chang Gung Research Database, largest electronic medical record-based database Patients during 2001-2016 included. Cox proportional hazard model was employed to compare outcomes between negative positive isolates after 1:1 propensity score matching. A total 19,647 enrolled 11,492 eligible for analysis exclusion screening. Finally, isolates-650 each-were analyzed divided into three groups: Pseudomonas aeruginosa (n = 53); fungus 26); concomitant P. 8). five single isolate 458); multiple 60); 89); 33); NTM, aeruginosa, 10). isolates; had independently associated failure death. or not related ventilator use, but both independent risk factor mortality. either combined fungus, exhibited more frequent exacerbations patients. Moreover, predicted mortality also correlated while concomitantly isolated fungus.