Risk Factors Associated With Human Papillomavirus Infection, Cervical Cancer, and Precancerous Lesions in Large-Scale Population Screening

• DOI: 10.3389/fmicb.2022.914516
• Publication Date: 2022-06-30T05:35:14Z
• Authors: Di Yang; Jing Zhang; Xiaoli Cui; Jian Ma; Chunyan Wang; Haozhe Piao
• Keywords: Papillomaviridae

Cervical cancer is the most common gynecological malignancy and screening for risk factors with early detection has been shown to reduce mortality. In this study, we aimed analyze characteristics of human papillomavirus (HPV) infection precancerous lesions in women provide clinical evidence developing strategies prevent cervical women. Furthermore, evaluated influencing high-risk HPV infection. From April 2018 December 2021, 10,628 were recruited at Liaoning Cancer Hospital, Shenyang Sujiatun District Women’s Infants Benxi Manchu Autonomous County People’s Shandong Affiliated Hospital Qingdao University. The study participants tested determine if they HPV-positive (HPV +) or underwent thinprep cytology test (TCT) atypical squamous cells undetermined significance (ASCUS) above. colposcopies biopsies performed histopathological examination. Finally, 9991 cases included statistical analysis, those related analyzed. + infection, high-grade intraepithelial lesion-positive (CINII neoplasia, diagnosis rates 12.45, 1.09, 95.41%, respectively. potential education ≤ high school [odds ratio (OR) = 1.279 (1.129–1.449), P < 0.001], age initial sexual activity 19 years [OR 1.517 (1.080–2.129), 0.016], partners > 1 1.310 (1.044–1.644), 0.020], ASCUS above 11.891 (10.105–13.993), non-condom contraception 1.255 (1.059–1.487), 0.009], HSIL 1.541 (1.430–1.662), 0.001]. Compared aged 56–65 35–45 0.810 (0.690–0.950), 0.010] rate was significantly lower 46–55 0.79 (0.683–0.915), 0.002]. 1.577 (1.042–2.387), 0.031], not breastfeeding 1.763 (1.109–2.804), 0.017], 42.396 (28.042–64.098), 0.001] lesions. level, age, number 1, above, contraception, years, had rates, below, non-breastfeeding, all