Causal effects of gut microbiota on erectile dysfunction: a two-sample Mendelian randomization study

• DOI: 10.3389/fmicb.2023.1257114
• Publication Date: 2023-10-19T07:31:50Z
• Authors: Yuyang Zhang; Yuxi Chen; Yangyang Mei; Renfang Xu; Hong Zhang; Xingliang Feng
• Keywords: Mendelian Randomization; Genome-wide Association Study; Pleiotropy

Several observational studies have reported the correlation between gut microbiota and risk of erectile dysfunction (ED). However, causal association them remained unestablished owing to intrinsic limitations, confounding factors, reverse causality. Therefore, two-sample Mendelian randomization (MR) study was performed determine effect on ED.The MR analysis utilized publicly available genome-wide (GWAS) summary-level data explore associations ED. The were extracted from MiBioGen (N = 18,340), ED IEU Open GWAS (6,175 cases 217,630 controls). single nucleotide polymorphisms (SNPs) served as instrumental variables (IVs) by two thresholds P-values, first P-value setting <1e-05 (locus-wide significance level) second <5e-08 (genome-wide level). inverse variance weighted approach used primary for analysis, supplemented with other methods. In addition, sensitivity analyses evaluate robustness results, including Cochran's Q test heterogeneity, MR-Egger intercept horizontal pleiotropy, pleiotropy residual sum, outlier (MR-PRESSO) global outliers, forest leave-one-out strong influence SNPs.Our results presented that increased abundance Lachnospiraceae at family level (OR: 1.265, 95% CI: 1.054-1.519), Senegalimassilia 1.320, 1.064-1.638), NC2004 group 1.197, 1.018-1.407), Tyzzerella3 1.138, 1.017-1.273), Oscillibacter 1.201, 1.035-1.393) genus may be factors ED, while Ruminococcaceae UCG013 0.770, 0.615-0.965) a protective No heterogeneity or found based previously described set analyses.Our demonstrated had inducing effects provide clinicians novel insights into treatment prevention in future. Furthermore, our also displays pathogenesis microbiota-mediated