Antimicrobial activity of nature-inspired molecules against multidrug-resistant bacteria

• DOI: 10.3389/fmicb.2023.1336856
• Publication Date: 2024-01-22T04:14:00Z
• Authors: Mohamad Hamad; Farah Al-Marzooq; Vunnam Srinivasulu; Ashna Sulaiman; Varsha Menon; Wafaa S. Ramadan; Raafat El-Awady; Taleb H. Al-Tel
• Keywords: Gram-Positive Bacteria

Multidrug-resistant bacterial infections present a serious challenge to global health. In addition the spread of antibiotic resistance, some bacteria can form persister cells which are tolerant most antibiotics and lead treatment failure or relapse. work, we report discovery new class small molecules with potent antimicrobial activity against Gram-positive moderate Gram-negative drug-resistant pathogens. The compound SIMR 2404 had minimal inhibitory concentration (MIC) 2 μg/mL methicillin-resistant Staphylococcus aureus (MRSA) vancomycin-intermediate (VISA). MIC values such as Escherichia coli Actinobacteria baumannii were between 8–32 μg/mL. Time-kill experiments show that rapidly kill tested bacteria. Compound was also found MRSA persisters display high levels tolerance conventional antibiotics. evolution experiments, quickly developed resistance ciprofloxacin but failed develop even after 24 serial passages. not toxic normal human fibroblast at 4 is twice MRSA. However, 8 higher, it showed cytotoxic indicating ideal candidate acceptable toxicity profile rapid antibacterial highlight potential these for further studies anti-MRSA agents.