Multi-omics-based investigation of Bifidobacterium’s inhibitory effect on glioma: regulation of tumor and gut microbiota, and MEK/ERK cascade

• DOI: 10.3389/fmicb.2024.1344284
• Publication Date: 2024-04-18T15:22:05Z
• Authors: Huali Fan; Yuhan Wang; Mingyu Han; Li Wang; Xue Li; Xi Kuang; Junrong Du; Fu Peng
• Keywords: 0301 basic medicine; 03 medical and health sciences; tumor microbiota; gut microbiota; glioma; MEK/ERK cascade; Bifidobacterium; serum metabolites; Microbiology; QR1-502

Glioma, the most prevalent primary tumor of central nervous system, is characterized by a poor prognosis and high recurrence rate. The interplay between microbes, such as gut microbiota, host has underscored significant impact microorganisms on disease progression. Bifidobacterium, beneficial bacterial strain found in human animal intestines, exhibits inhibitory effects against various diseases. However, existing body evidence pertaining to influence Bifidobacterium glioma remains insufficient. Here, we that reduces volume prolongs survival time an orthotopic mouse model glioma. Experiments elucidated suppresses MEK/ERK cascade. Additionally, noted increase α-diversity along with augmented relative abundance microbiota. This rise levels within intestine may be attributed concurrent induced alterations serum metabolites, particularly those comprised organonitrogen compounds. Thus, our findings showed can suppress growth inhibiting cascade regulating tumor, metabolites mice, indicating promising therapeutic prospects