Advanced fructo-oligosaccharides improve itching and aberrant epidermal lipid composition in children with atopic dermatitis

• DOI: 10.3389/fmicb.2024.1383779
• Publication Date: 2024-04-29T04:34:06Z
• Authors: Sukyung Kim; Bae-Gon Kang; Soonok Sa; Se Young Park; Kyungheon Ryu; Jinyoung Lee; Boram Park; Mijeong Kwon; Yeonghee Kim; Jiwon Kim; Sanghee Shin; Sehun Jang; Byung Eui Kim; Jaewoong Bae; Kangmo Ahn; Kwang-Hyeon Liu; Jihyun Kim
• Keywords: Itching

Introduction The effects of fructo-oligosaccharides (FOS) on atopic dermatitis (AD) have not been determined. Methods In a randomized, double-blind, placebo-controlled trial, children with AD aged 24 months to 17 years received either advanced FOS containing 4.25 g 1-kestose or placebo (maltose) for 12 weeks. Results SCORAD and itching scores were reduced in patients treated both (all p < 0.01) maltose ( 0.05 0.01). Sleep disturbance was improved only the group revealed decreased proportion linoleic acid (18:2) esterified omega-hydroxy-ceramides (EOS-CERs) amide-linked shorter chain fatty acids (C28 C30, all 0.05), along an increased EOS-CERs longer (C32, Discussion may be beneficial alleviating sleep disturbance, as well improving skin barrier function AD.