Exploring of gut microbiota features in dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography

• DOI: 10.3389/fmicb.2024.1384146
• Publication Date: 2024-04-05T04:59:33Z
• Authors: Wongsakorn Luangp...; Pinidphon Prombutara; Viroj Muangsillap...; Damrong Sukitpuny...; Eric Eeckhout; Malai Taweechotipatr
• Keywords: Dyslipidemia; Lachnospiraceae; Roseburia; Fusobacteria; Dysbiosis; Ruminococcus

Chronic coronary syndrome (CCS) has a high mortality rate, and dyslipidemia is major risk factor. Atherosclerosis, cause of CCS, influenced by gut microbiota dysbiosis its metabolites. The objective this study was to the diversity composition related clinical parameters among CCS patients undergoing angiography in comparison healthy volunteers Thailand. had more factors higher inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) than others. alpha lower group. A significant difference observed three groups. relative abundance Proteobacteria, Fusobacteria, Enterobacteriaceae, Prevotella, Streptococcus significantly increased while Roseburia , Ruminococcus, Faecalibacterium were patients. In patients, Lachnospiraceae, Peptostreptococcaceae, Pediococcus positively correlated with hs-CRP. Megasphaera strongly triglyceride (TG) level negatively high-density lipoprotein cholesterol (HDL-C). modification associated changes involved development artery disease (CAD)