Targeting bacterial biofilm-related genes with nanoparticle-based strategies

• DOI: 10.3389/fmicb.2024.1387114
• Publication Date: 2024-05-22T04:35:23Z
• Authors: Shima Afrasiabi; Alireza Partoazar
• Keywords: Efflux

Persistent infection caused by biofilm is an urgent in medicine that should be tackled new alternative strategies. Low efficiency of classical treatments and antibiotic resistance are the main concerns persistent due to formation which increases risk morbidity mortality. The gene expression patterns cells differed from those planktonic cells. One promising approaches against biofilms nanoparticle (NP)-based therapy NPs with multiple mechanisms hinder bacterial or forms. For instance, such as silver (Ag), zinc oxide (ZnO), titanium dioxide (TiO 2 ), copper (Cu), iron (Fe 3 O 4 ) through different strategies interfere bacteria associated biofilm. can penetrate into structure affect efflux pump, quorum-sensing, adhesion-related genes, lead inhibit development. Therefore, understanding targeting genes molecular basis point therapeutic targets make possible control infections. In parallel, impact on environment their cytotoxicity avoided controlled exposure safety assessments. This study focuses biofilm-related potential for inhibition highly effective NPs, especially metal NPs.