Molecular Associations and Clinical Significance of RAPs in Hepatocellular Carcinoma

• DOI: 10.3389/fmolb.2021.677979
• Publication Date: 2021-06-21T04:19:31Z
• Authors: Sarita Kumari; Mohit Arora; Jay Singh; Lokesh K. Kadian; Rajni Yadav; Shyam S. Chauhan; Anita Chopra
• Keywords: 0301 basic medicine; 03 medical and health sciences; QH301-705.5; Molecular Biosciences; hepatocellular carcinoma; prognosis; biomarker 3; TCGA; Biology (General); liver; RAP; 3. Good health

Hepatocellular carcinoma (HCC) is an aggressive gastrointestinal malignancy with a high rate of mortality. Multiple studies have individually recognized members RAP gene family as critical regulators tumor progression in several cancers, including hepatocellular carcinoma. These suffer numerous limitations small sample size and lack analysis various clinicopathological molecular features. In the current study, we utilized authoritative multi-omics databases to determine association expression detailed features (HCC). All five genes were observed harbor dysregulated HCC compared normal liver tissues. RAP2A exhibited strongest ability differentiate tumors from was associated progressive grade, TP53 CTNNB1 mutation status. Additionally, alteration its copy numbers DNA methylation. also emerged independent marker for patient prognosis. Further, pathway revealed that correlated tumor-infiltrating immune cell composition oncogenic pathways, such cycle cellular metabolism.