Potential Value of TNF-α (–376 G/A) Polymorphism and Cystatin C (CysC) in the Diagnosis of Sepsis Associated Acute Kidney Injury (S-AK I) and Prediction of Mortality in Critically Ill patients

• DOI: 10.3389/fmolb.2021.751299
• Publication Date: 2021-10-07T01:50:07Z
• Authors: Hiba S Al-Amodi; Shimaa Abdelsattar; Zeinab A. Kasemy; Hanan M. Bedair; Hany S. Elbarbary; Hala F. M. Kamel
• Keywords: Clinical Significance

Sepsis Associated Kidney Injury represents a major health concern as it is frequently associated with increased risk of mortality and morbidity. We aimed to evaluate the potential value TNF-α (-376 G/A) cystatin C in diagnosis S-AKI prediction critically ill patients. This study included 200 patients healthy controls. Patients were categorized into 116 acute septic shock 84 sepsis, from which 142 (71%) developed S-AKI. Genotyping was performed by RT-PCR serum CysC assessed Enzyme Linked Immunosorbent Assay. Our results showed highly significant difference genotype frequencies SNP between non-AKI (p < 0.001). Additionally, sCysC levels significantly higher group = 0.011). The combination both together had better diagnostic ability for than alone (AUC 0.610, 0.838, respectively). Both GA AA genotypes independent predictors (p= 0.001, p 0.002 development (Odds Ratio 1.111). non-survival 0.001), suggesting their role mortality.