Serum 25-hydroxyvitamin D level and erectile dysfunction: a causal relationship? Findings from a two-sample Mendelian randomization study

• DOI: 10.3389/fmolb.2024.1390814
• Publication Date: 2024-06-12T07:16:55Z
• Authors: Hengchang Sun; Gang Shen; Huimin Dong; Mei Shang; Wenying Zhou; Lingling Wang; Zhaoxia Li; Jiao Gong; Bo Hu
• Keywords: Mendelian Randomization; Pleiotropy; Genome-wide Association Study; Genetic Association; SNP

Background Serum 25-hydroxyvitamin D level is associated with erectile dysfunction (ED) in observational studies. However, whether there a causal association between them remains uncertain. Objective Conduct two-sample Mendelian randomization (MR) analysis to investigate the effect serum and ED risk. Method Genome-wide study (GWAS) data of levels comprising 6,896,093 single nucleotide polymorphisms (SNP) from 496,949 people European ancestry were regarded as exposure for MR analysis. Additional GWAS involving 9,310,196 SNPs 6,175 cases 217,630 controls used outcome data. The MR-Egger, inverse variance weighted (IVW) method, median, simple mode, mode employed evaluate effects, among which IVW was primary method. stability results confirmed by heterogeneity test, horizontal pleiotropy leave-one-out Result There 103 utilized instrumental variables ( p < 5 × 10 −8 ). showed no effects 25(OH) concentration on risks (IVW; OR = 0.9516, 95% CI 0.7994 1.1328, 0.5772). statistical models. Conclusion present did not support genetically predicted risk individuals descent.